Refractory anemia (RA)

Refractory megaloblastic anemia.

Dyserythropoiesis , Refractory Anemia , and “

Twenty-one enzymatic activities and red cell glutathione content are compared in cord blood, dyserythropoietic disorders, normal subjects, and subjects with hemolytic syndromes and reticulocytosis approximating that of the newborn. The dyseryth ropoietic states are heterogeneous and include several hereditary disorders, “preleukemia” and overt leukemia, refractory anemia with and without marrow...

Iron-Refractory Iron Deficiency Anemia

Iron is essential for life because it is indispensable for several biological reactions, such as oxygen transport, DNA synthesis, and cell proliferation. Over the past few years, our understanding of iron metabolism and its regulation has changed dramatically. New disorders of iron metabolism have emerged, and the role of iron as a cofactor in other disorders has begun to be recognized. The stu...

Dyserythropoiesis , Refractory Anemia , and “ Preleukemia : ”

Twenty-one enzymatic activities and red cell glutathione content are compared in cord blood, dyserythropoietic disorders, normal subjects, and subjects with hemolytic syndromes and reticulocytosis approximating that of the newborn. The dyseryth ropoietic states are heterogeneous and include several hereditary disorders, “preleukemia” and overt leukemia, refractory anemia with and without marrow...

Iron refractory iron deficiency anemia.

Iron refractory iron deficiency anemia is a hereditary recessive anemia due to a defect in the TMPRSS6 gene encoding Matriptase-2. This protein is a transmembrane serine protease that plays an essential role in down-regulating hepcidin, the key regulator of iron homeostasis. Hallmarks of this disease are microcytic hypochromic anemia, low transferrin saturation and normal/high serum hepcidin va...